MADlib
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Generally, applications start with a list of \( \boldsymbol n \) observations, each with \( \boldsymbol m \) covariates and a time of death. From this \( \boldsymbol n \times m \) matrix, we would like to derive the correlation between the covariates and the hazard function. This amounts to finding the parameters \( \boldsymbol \beta \) that best fit the model described below.
Let us define:
Note that this model does not include a constant term, and the data cannot contain a column of 1s.
By definition,
\[ P[T_k = t_i | \boldsymbol R(t_i)] = \frac{e^{\beta^T x_k} }{ \sum_{j \in R(t_i)} e^{\beta^T x_j}}. \,. \]
The partial likelihood function can now be generated as the product of conditional probabilities:
\[ \mathcal L = \prod_{i = 1}^n \left( \frac{e^{\beta^T x_i}}{ \sum_{j \in R(t_i)} e^{\beta^T x_j}} \right). \]
The log-likelihood form of this equation is
\[ L = \sum_{i = 1}^n \left[ \beta^T x_i - \log\left(\sum_{j \in R(t_i)} e^{\beta^T x_j }\right) \right]. \]
Using this score function and Hessian matrix, the partial likelihood can be maximized using the Newton-Raphson algorithm . Breslow's method is used to resolved tied times of deaths. The time of death for two records are considered "equal" if they differ by less than 1.0e-6
The inverse of the Hessian matrix, evaluated at the estimate of \( \boldsymbol \beta \), can be used as an approximate variance-covariance matrix for the estimate, and used to produce approximate standard errors for the regression coefficients.
\[ \mathit{se}(c_i) = \left( (H)^{-1} \right)_{ii} \,. \]
The Wald z-statistic is
\[ z_i = \frac{c_i}{\mathit{se}(c_i)} \,. \]
The Wald \( p \)-value for coefficient \( i \) gives the probability (under the assumptions inherent in the Wald test) of seeing a value at least as extreme as the one observed, provided that the null hypothesis ( \( c_i = 0 \)) is true. Letting \( F \) denote the cumulative density function of a standard normal distribution, the Wald \( p \)-value for coefficient \( i \) is therefore
\[ p_i = \Pr(|Z| \geq |z_i|) = 2 \cdot (1 - F( |z_i| )) \]
where \( Z \) is a standard normally distributed random variable.
The condition number is computed as \( \kappa(H) \) during the iteration immediately preceding convergence (i.e., \( A \) is computed using the coefficients of the previous iteration). A large condition number (say, more than 1000) indicates the presence of significant multicollinearity.
The training data is expected to be of the following form:
{TABLE|VIEW} sourceName ( ... dependentVariable FLOAT8, independentVariables FLOAT8[], ... )
Note: Dependent Variables refer to the time of death. There is no need to pre-sort the data. Additionally, all the data is assumed
SELECT * FROM cox_prop_hazards( 'sourceName', 'dependentVariable', 'independentVariables' [, numberOfIterations [, 'optimizer' [, precision ] ] ] );Output: Output:
coef | log_likelihood | std_err | z_stats | p_values | condition_no | num_iterations ...
SELECT (cox_prop_hazards('sourceName', 'dependentVariable', 'independentVariables')).coef;
SELECT coef, log_likelihood FROM cox_prop_hazards('sourceName', 'dependentVariable', 'independentVariables');
sql> SELECT * FROM data; val | time ------------|-------------- {0,1.95} | 35 {0,2.20} | 28 {1,1.45} | 32 {1,5.25} | 31 {1,0.38} | 21 ...
sql> SELECT * FROM cox_prop_hazards('data', 'val', 'time', 100, 'newto', 0.001); ---------------|-------------------------------------------------------------- coef | {0.881089349817059,-0.0756817768938055} log_likelihood | -4.46535157957394 std_err | {1.16954914708414,0.338426252282655} z_stats | {0.753356711368689,-0.223628410729811} p_values | {0.451235588326831,0.823046454908087} condition_no | 12.1135391339082 num_iterations | 4
A somewhat random selection of nice write-ups, with valuable pointers into further literature:
[1] John Fox: Cox Proportional-Hazards Regression for Survival Data, Appendix to An R and S-PLUS companion to Applied Regression Feb 2012, http://cran.r-project.org/doc/contrib/Fox-Companion/appendix-cox-regression.pdf
[2] Stephen J Walters: What is a Cox model? http://www.medicine.ox.ac.uk/bandolier/painres/download/whatis/cox_model.pdf